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Get your rhythm back.

Serious heart rhythm disorders called arrhythmias, affect the lives of millions of people daily. Unfortunately, most treatments for these conditions are generic and one-size-fits-all, with mixed results.


But there’s hope.


We believe there is a better way to treat serious heart rhythm disorders such as atrial fibrillation and ventricular tachycardia. Using Abbott Electrophysiology’s technology, doctors can identify the sources of arrhythmias that are unique to each person. Now treatment can be tailored to your individual needs.


Find Your Source.
Get Tailored Therapy.
Get Your Rhythm Back.

Find a doctor near you who is using the Topera Rotor Mapping System

The most common heart rhythm disorder, atrial fibrillation (AF, or afib) is a serious global public health problem which affects millions of people around the world. If left untreated, AF doubles the risk of heart-related deaths and also increases stroke risk by up to 500%. Unfortunately, although it is such a serious health problem, AF has historically been difficult to treat with an acceptable degree of success.

In response to this unaddressed need, Abbott, Inc. has developed a unique 3D analysis and mapping solution (the Abbott 3D Mapping System), which consists of the RhythmView Workstation and FIRMap diagnostic catheter. The Abbott 3D Mapping System has been designed to enable physicians to view the electrical activity of the heart, thereby supporting the diagnosis and patient-specific treatment planning for a variety of heart arrhythmias including atrial fibrillation, atrial flutter, atrial tachycardia, and ventricular tachycardia.

The Abbott 3D Mapping System received FDA clearance in 2013 and is now in routine use at several leading medical centers throughout the United States.

Bibliography

Clinical References
Technology-Related Publications & Presentations: 2011-2016

The RhythmView® Workstation is a computerized system that assists in the diagnosis of complex cardiac arrhythmias. The RhythmView Workstation is used to analyze electrogram and electrocardiogram signals and display them in a visual format.

The FIRMap® Catheter is indicated for use in cardiac electrophysiology procedures to assist in the diagnosis of complex arrhythmias that may be difficult to identify using conventional mapping systems alone (i.e., linear mapping catheters). The FIRMap Catheter may also be used for delivery of externally generated pacing stimuli.

Accurate diagnosis and identification of arrhythmia sources is crucial for successful treatment of arrhythmias. Study-to-study comparisons may not reflect individual experience, as variations exist in treatment regimen, patient condition, and study design. Published clinical studies may have been conducted in different patient populations and have varying definitions of treatment success.

Review all aspects of published studies to be fully informed as to the strengths and weaknesses of any particular study.

Copies of published articles and RhythmView labeling are available on request. Any questions regarding the publications or clinical use of RhythmView Workstation should be directed to our medical affairs team.


 

Publications

  1. Sommer P, Bollmann A, Hindricks G. About Specific Targets and Collateral Damage. J Am Coll Cardiol 2016;68:283-285.
  2. Berntsen RF, Haland TF, Skardal R, et al. Focal impulse and rotor modulation as a stand-alone procedure for treatment of paroxysmal atrial fibrillation: A within-patient controlled study with implacted cardiac monitoring. Heart Rhythm 2016; in press.
  3. Buch E, Share M, Tung R, et al. Long-term clinical outcomes of focal impulse and rotor modulation for treatment of atrial fibrillation: A multicenter experience Heart Rhythm 2016; 13(3): 636–641.
  4. Gianni C, Mohanty S, Di Biase L, et al. Acute and early outcomes of focal impulse and rotor modulation (FIRM)-guided rotors-only ablation in patients with nonparoxysmal atrial fibrillation. Heart Rhythm 2016;13(4):830-835.
  5. Sommer P, Kircher S, Rolf S et al. Successful Catheter Ablation of Recurrent Longstanding Persistent Atrial Fibrillation with Rotor Elimination as the Procedural Endpoint: A Case Series. J Cardiovasc Electrophysiol 2016;27:274-280.
  6. Zaman J, Baykaner T, Narayan SM. New mechanism-based approaches to ablating persistent AF- will drug therapy soon be obsolete? J Cardiovasc Pharm 2016; 67(1):1-8.
  7. Rashid H, Sweeney A. Approaches for Focal Impulse and Rotor Mapping in Complex Patients: A US Private Practice Experience. J Innov CRM 2015; 6:2193-2198.
  8. Tomassoni G, Duggal S, Muir M, et al. Long-term Follow-up of FIRM-guided Ablation of Atrial Fibrillation: A Single-Center Experience. J Innov CRM 2015; 6:2145-2151.
  9. Hummel JD, Fedorov VV. Targeting Atrial Fibrillation Rotors; does being close count? 2015;1(4):270-272.
  10. Zaman JA, Narayan SM. Ablating Atrial Fibrillation: Customizing Lesion Sets Guided by Rotor Mapping. Methodist Debakey Cardiovasc J 2015; 11(2)76-81.
  11. Rappal WJ, Zaman JA, Narayan SM. Mechanisms for the Termination of Atrial Fibrillation by Localized Ablation: Computational and Clinical Studies. Circ Arrhythm Electrophysiol. 2015; pii: CIRCEP.115.002956.
  12. Verma A, Narayan SM. Is Human Long-Standing Persistent Atrial Fibrillation More Stable Than Assumed? J Am Coll Cardiol Clin Electrophysiol 2015; 1:25-28.
  13. Krummen DE, Hayase J, Vampola SP, et al. Modifying Ventricular Fibrillation by Targeted Rotor Substrate Ablation: Proof-of-Concept from Experimental Studies to Clinical VF. J Cardiovasc Electrophysiol. 2015; doi:10.111/jce.12753.
  14. Schricker AA, Zaman J and Narayan S. Role of Rotors in the Ablative Therapy of Persistent Atrial Fibrillation. Arrhythmia and Electrophysiol Review 2015;4(1):47-52.
  15. Lin T, Rilig A, Bucur T, et al. Focal Impulse and Rotor Modulation (FIRM) using the novel 64-electrode basket catheter: Electrogram characteristics of human rotors. Europace 2015; In Press.
  16. Zaman J, Peters NS, Narayan SM. Rotor mapping and ablation to treat atrial fibrillation. Curr Opin Cardiol 2015; 30:24-32.
  17. Krummen DE, Swarup V, Narayan SM. The role of rotors in atrial fibrillation. J Thorac Dis 2015;7(2):142-151.
  18. Lalani GG, Trikha R, Krummen DE, et al. Rotors and Focal Sources for Human Atrial Fibrillation- Mechanistic Paradigm with Director Clinical Relevance. Circ J 2014; 78:2357-2366.
  19. Schricker AA, Lalani GG, Krummen DE, et al. Human Atrial Fibrillation Initiates Via Organized Rather Than Disorganized Mechanisms. Circ Arrhythm Electrophysiol. 2014: DOI: 10.1161/CIREP.113.001289.
  20. Swarup V, Baykaner T, Rostamian A, et al. Stability of Rotors and Focal Sources For Human Atrial Fibrillation: Focal Impulse and Rotor Mapping (FIRM) of AF Sources and Fibrillatory Conduction. J Cardiovasc Electrophysiol 2014;doi: 10.1111/jce.12559.
  21. Zaman J, Schricker A, Lalani GG, et al. Focal Impulse and Rotor Mapping (FIRM): Conceptualizing and Treating Atrial Fibrillation. J Afib 2014;7(2):47-54.
  22. Narayan SM and Jalife J. Rotors have been demonstrated to drive human atrial fibrillation. J Physiol. 2014;592(15):3163-3166.
  23. Schricker AA, Lalani G, et al. Rotors as Drivers of Atrial Fibrillation and Targets for Ablation. Curr Cardiol Rep. 2014;16:509.
  24. Miller JM, Kowal RC, Swarup V et al. Initial Independent Outcomes from Focal Impulse and Rotor Modulation Ablation for Atrial Fibrillation: Multicenter FIRM Registry. J Cardiovasc Electrophysiol. 2014; doi:10.111/jce.12474.
  25. Safavi-Naeini P, Razavi M, Massumi A, et al. Review: Focal Impulse and Rotor Modulation (FIRM) Ablation. EP Lab Digest, June 2014 Vol 14 No 6.
  26. Krummen DE, Swarup V, et al. What is an Atrial Fibrillation Rotor – In Patients? Rationale for Focal Impulse and Rotor Mapping (FIRM). EP Lab Digest, May 2014 Vol 14 No 5.
  27. Krummen DE, et al. Rotor Stability Separates Sustained Ventricular Fibrillation From Self-Terminating Episodes in Humans. J Am Coll Cardiol. 2014; DOI 10.1016.
  28. Narayan SM, et al. Ablation of Rotor and Focal Sources Reduces Late Recurrence of Atrial Fibrillation Compared to Trigger Ablation Alone. J Am Coll Cardiol. 2014;63(17):1761-1768.
  29. Lin T, Kuck KH, et al. First in-human robotic rotor ablation for atrial fibrillation. Eur Heart J. 2014.
  30. Baykaner T, et al. Mapping and ablating stable sources for atrial fibrillation: summary of the literature on Focal Impulse and Rotor Modulation (FIRM). J Interv Card Electrophysiol. 2014.
  31. Hayase J, et al. A case of a human ventricular fibrillation rotor localized to ablation sites for scar-mediated monomorphic ventricular tachycardia. Heart Rhythm 2013.
  32. Narayan SM, et al. Direct Or Coincidental Elimination of Stable Rotors or Focal Sources May Explain Successful Atrial Fibrillation Ablation: On-Treatment Analysis of the CONFIRM Trial. J Am Coll Cardiol 2013.
  33. Baykaner T, et al. Targeted Ablation at Stable Atrial Fibrillation Sources Improves Success Over Conventional Ablation in High-Risk Patients: A Substudy of the CONFIRM Trial. Can J Cardiol. 2013.
  34. KAWATA H, et al. Focal Impulse and Rotor Modulation for Paroxysmal Atrial Fibrillation. J Innovations in Cardiac Rhythm Management. February, 2013.
  35. Narayan SM, et al. Panoramic Electrophysiological Mapping But Not Individual Electrogram Morphology Identifies Sustaining Sites for Human Atrial Fibrillation: Stable AF Rotors and Focal Sources Relate Poorly to Fractionated Electrograms. Circulation Arrhythm Electrophysiol. 2013; 6: 58-67.
  36. Orlov MV, et al. Rotors of truly atypical atrial flutters visualized by FIRM mapping and 3D-MRI overlay on live fluoroscopy. J Interv Card Electrophysiol. 2013.
  37. Sehra R, et al. Thinking outside the Box: Rotor Modulation in the Treatment of Atrial Fibrillation. JAFib 2013.
  38. Rappel WJ and Narayan SM. Theoretical considerations for mapping activation in human cardiac fibrillation. Chaos 2013.
  39. Krummen DE, et al. Focal Impulse and Rotor Modulation (FIRM) for the treatment of paroxysmal and persistent atrial fibrillation (AF). EP Lab Digest January 2013; 13(1).
  40. Narayan SM, et al. Targeting Stable Rotors to Treat Atrial Fibrillation. Arrhythm and Electrophysiol. Rev. 2012; 1: 34-48.
  41. Narayan SM, et al. Computational Identification and Ablation of Localized Sources for Human Atrial Fibrillation. Plos One 2012; 7(9):e46034.
  42. Narayan SM, et al. Focal Impulse and Rotor Modulation (FIRM) Ablation of Sustaining Rotors Abruptly Terminates Persistent Atrial Fibrillation To Sinus Rhythm With Elimination On Followup. Heart Rhythm 2012; 9(9): 1436-9.
  43. Narayan SM, et al. Ablating Rotors and Focal Beat Sources of Atrial Fibrillation to Improve Outcome: The CONFIRM Trial. EP Lab Digest March 2012; 12(3).
  44. Narayan SM, et al. Treatment of Atrial Fibrillation by the Ablation of Localized Sources: The CONventional Ablation For Atrial Fibrillation With and Without Focal Impulse and Rotor Modulation (CONFIRM) Trial. J Am Coll Cardiol 2012; 60(7):628-36.
  45. Narayan SM, et al. Clinical Mapping Approach To Diagnose Electrical Rotors and Focal Impulse Sources for Human AF. J Cardiovasc Electrophys 2012; 23(5): 447-454.
  46. Franz MR, et al. The Role of Action Potential Alternans in the Initiation of Atrial Fibrillation in Humans: a Review and Future Directions. Europace 2012.
  47. Baykaner T, et al. Temporal and Spatial Indices of AF Regularization Predict Intraprocedural AF Termination and Outcome. J AFib 2012.
  48. Shivkumar K, et al. Acute termination of human atrial fibrillation by identification and catheter ablation of localized rotors and sources: first multicenter experience of focal impulse and rotor modulation (FIRM) ablation. J Cardiovasc Electrophysiol. December 2012; 23 (12):1277-85.


 

Presentations And Other Publications

  1. Spitzer SG, Karolyi L, Raemmler C, et al. Redo-ablation in patients with atrial fibrillation- Procedural results and 12-months follow-up after FIRM-guided ablation strategy. Eur Heart J 2016;37(suppl):1081.
  2. Noelker G, Szili-Torok T, Spitzer SG, et al. Outcome and procedural parameters in atrial fibrillation ablation guided by focal impulse and rotor mapping: results from the European focal impulse and rotor modulation registry. Eur Heart J;2016:37(suppl):1077-1078.
  3. Rashid H, Fein A, Frandsen T, Sweeny A. The Relationship Between Rotors and Obstructive Sleep Apnea in Patients with Long-standing Persistent AF. Europace 2016;18(suppl 1):i37.
  4. Adragao P, Carmo P, Cavaco D, et al. Atrial Fibrillation Targeting Rotors: Quantification and Most Frequent Locations. Europace 2016;18(suppl 1):i37.
  5. Spitzer SG, Karolyi L, Rammler C, et al. FIRM-Guided Ablation in Redo Cases of Paroxysmal/Persistent Atrial Fibrillation- Procedural Data and 12-Months Results. Europace 2016;18(suppl 1):i163.
  6. Krummen D, Hayase J, Faiwiszewski Y, et al. Functional Substrates are Associated with Ventricular Arrhythmia Recurrence Following Ablation. Europace 2016;18(suppl 1):i69.
  7. Szili-Torok T, Nolker G, Spitzer S et al. European-Focal Impulse and Rotor Modulation Registry- First Results of the E-FIRM Registry. Europace 2016;18(suppl 1):i140.
  8. Langbein A, Karolyi L, Rammler C, et al. Evidence for a Correlation Between Rotor Activity and Atrial Fibrosis in Patients with Atrial Fibrillation. Europace 2016;18(suppl 1):i179.
  9. Kowalewski C, Zaman J, Baykaner T et al. Why are Human Atrial Fibrillation Maps So Different? Filtering Far Field Signals Using Repolarization Reveals Sources. Europace 2016;18(suppl 1):i140.
  10. Rogers A, Zaman J, Baykaner T, et al. Comorbidities Influence the Inability of Classical Activation Mapping to Identify Sites Where Ablation Terminates Persistent AF. Europace 2016;18(suppl 1):i96.
  11. Rogers A, Zaman J, Lalani G, et al. Mechanisms to Explain Why Activation Maps are Limited in Identifying Sites Where Ablation Terminates Atrial Fibrillation. Europace 2016;18(suppl 1):i138.
  12. Baykaner T, Zaman JA, Narayan SM, et al. Clinical efficacy of rotor ablation for atrial fibrillation: A systematic review. Heart Rhythm 2016; PO04-90.
  13. Miller JM, Das Mithilesh KD, Dandamudi G, et al. Single-center experience with rotor mapping and ablation for treatment of atrial fibrillation in 170 patients. Heart Rhythm 2016; PO01-50.
  14. Natale A, Mohanty S, Gianni C, et al. Impact of rotor ablation in non-paroxysmal AF patients: results from a randomized trial (OASIS). Heart Rhythm 2016; LBCT02-01
  15. Schricker AA, Baykaner T, Zaman JA et al. Indexes of effective basket placement predict successful outcome from atrial fibrillation rotor ablation. Heart Rhythm 2016; PO03-167.
  16. Rashid H, Fein AS, Sweeney A. The relationship between stable rotors and obstructive sleep apnea in patients with long-standing persistent AF. Heart Rhythm 2016; PO03-160.
  17. Kalra V, Hamilton J, Garlie JB et al. Termination of atrial fibrillation guided by rotor mapping: impact on long-term outcomes. Heart Rhythm 2016; PO03-160.
  18. Jain R, Garlie JB, Hamilton J, et al. Area of rotors with Focal Impulse and Rotor Modification (FIRM) technique and its correlation with body mass index. Heart Rhythm 2016; PO03-120.
  19. Tomassoni GF, Muir M, Turner K, et al. Clinical and electrophysiological characteristics of failed catheter ablation guided by Focal Impulse and Rotor Modulation (FIRM). Heart Rhythm 2016; PO04-130.
  20. Voss J, Vetter B, Winterfield JR, et al. Atrial fibrillation termination with FIRM ablation. Heart Rhythm 2016; PO05-99.
  21. Steinberg JS, Shah Y, Musat DL, et al. Focal Impulse and Rotor Modulation: Acute procedural observations and extended clinical follow-up. Heart Rhythm 2016; PO01-56.
  22. Ho D, Nasir JM, Brodt CR, et al. Identification of post-AF ablation atrial tachycardias using FIRM mapping. Heart Rhythm 2016; PO02-178.
  23. Ho D, Nasir JM, Brodt CR, et al. Termination of persistent atrial fibrillation at a stable AF rotor identified one hour earlier. Heart Rhythm 2016; PO06-183.
  24. Spitzer SG, Karolyi L, Rammler C, et al. Rotor-Mapping and Ablation in Re-Do Cases of Persistent Atrial Fibrillation- Procedural and Follow-up Data. Presented at the Orlando International AF Symposium, 2016.
  25. Hansen BJ, Briggs C, Moore BT, et al. Human Atrial Fibrillation Drivers Seen Simultaneously by Focal Impulse and Rotor Mapping and High-Resolution Optical Mapping. The AHA Scientific Sessions 2015.
  26. Zaman JA, Lalani GG, Baykaner T, et al. Electrogram Amplitude is Reduced at Rotor Sites Critical to Maintenance of Human Persistent Atrial Fibrillation. The AHA Scientific Sessions 2015.
  27. Schricker AA, Baykaner T, Zaman J, et al. Impact of Right and Left Atrial Remodeling on Outcomes From Atrial Fibrillation Rotor Ablation. The AHA Scientific Sessions 2015.
  28. Schricker AA, Baykaner, T, Zaman J, et al. Defining Clinical Indexes of Good Basket Placement that Predict Successful Outcome From Atrial Fibrillation Rotor Ablation. The AHA Scientific Sessions 2015.
  29. Vitali Serdoz L, Halbfass P, Mahnkopf C, Brachmann J. Biatrial rotor ablation guided by FIRM basket map: initial single center experience. Europace 2015: P1590.
  30. Krummen DE, Bender AB, Vampola SP et al. Substrate dependence of ventricular fibrillation rotors. Europace 2015: P267.
  31. Schade A, Halbfass P, Mueller P, et al. FIRM only ablation in patients with persistent atrial fibrillation: acute and medium term results. Europace 2015: P462.
  32. Nentwich KM, Halbfass P, Mueller P et al. Analysis of redo-procedures out of the FIRM only study cohort. Europace 2015: P981.
  33. Spitzer SG, Karolyi L, Raemmler C et al. Rotor mapping and ablation in redo cases of persistent atrial fibrillation: procedural data. Europace 2015: P304.
  34. Schade A, Mueller P, Halbfass P et al. Spatial relationship of focal impulses, rotors and low voltage zones in patients with persistent atrial fibrillation. Europace 2015: P830.
  35. Krummen DE, Baykaner T, Swarup V et al. Multicenter safety of focal impulse and rotor modulation (FIRM) ablation. Europace 2015: P309.
  36. Tilz RR, Lin T, Rilig A et al. Nine months outcomes following focal impulse and rotor modulation for the treatment of atrial fibrillation using the novel 64-electrode basket catheter. Europace 2015: P192.
  37. Hayase J et al. Poorer Patient Outcomes Associated with Greater VF Rotor Prevalence and Stability at Baseline Ventricular Arrhythmia Ablation Procedure. Heart Rhythm 2015; PO03-134.
  38. Zuman JA, et al. Similarity of Substrates in Patients with Post-Ablation Recurrent Paroxysmal Atrial Fibrillation Versus Persistent Atrial Fibrillation: A 10-center Prospective study. Heart Rhythm 2015; AB35-04.
  39. Krummen DE et al. Ventricular Fibrillation Rotor Ablation Decreases Arrhythmia Susceptibility in a Canine Model. Heart Rhythm 2015; PO03-20.
  40. Miller JM. Catheter Mapping and Ablation of AF Rotors. Heart Rhythm 2015; Oral Presentation.
  41. Narayan SM. Mapping and Ablation of Rotors in Non-Paroxysmal AF: Techniques and Outcomes. Heart Rhythm 2015; Oral Presentation.
  42. Voss J, et al. Initial Experience with Sequential Rotor Mapping and Association with DE-MRI. Heart Rhythm 2015; PO06-59.
  43. Schricker AA, et al. Targeting Rotors in Two Patients with Recurrent AF and Isolated Pulmonary Veins. Heart Rhythm 2015; PO03-216.
  44. Krummen DE, et al. Elimination of Previously Intractable Ventricular Fibrillation by Targeted Ablation of Rotors in a Patient with Recurrent ICD Shocks. Heart Rhythm 2015; AB41-01.
  45. Narayan SM, et al. Mechanisms To Explain how Ablation May Terminate AF Rotors. A Clinical and Computational Study. Heart Rhythm 2015; PO03-12.
  46. Bender A, et al. Ventricular Fibrillation Rotors Predominantly Localize to Scar and Borderzone Tissue. Heart Rhythm 2015; PO02-136.
  47. Shigeki K, et al. Interpretation of Source Locations in Focal Impulse and Rotor Mapping (FIRM) System for Atrial Fibrillation: An Inter-Observer Analysis for Accuracy. Heart Rhythm 2015; PO04-121.
  48. Krummen D et al. Multicenter Procedural Safety of FIRM Ablation. Heart Rhythm 2015; PO05-127.
  49. Tomassoni G. Focal Impulse and Rotor Modulation: BHL Two Year Results. Heart Rhythm 2015 CME satellite symposium.
  50. Houmsee et al. Long-Term Outcome of FIRM Guided Rotor Ablation for Atrial Fibrillation. Heart Rhythm 2015; PO03-120.
  51. Foreman et al. Single Center Experience with FIRM Ablation: A Case Series of 193 Patients. Heart Rhythm 2015; PO01-56.
  52. Share et al. Long-term Outcomes of Focal Impulse and Rotor Modulation (FIRM) for Treatment of Atrial Fibrillation: A Multi-Center Experience. Heart Rhythm 2015; PO01-70.
  53. Gianni et al. Acute and Short-Term Outcomes in Persistent and Long-Standing Persistent Patients Undergoing Rotors Only Ablation. Heart Rhythm 2015; PO01-58.
  54. Narayan, et al. Long-Term Freedom From Paroxysmal Atrial Fibrillation By Eliminating Localized Sources Without Pulmonary Vein Isolation. Heart Rhythm 2015; PO01-29.
  55. Deneke et al. FIRM-Only in Patients with Persistent Atrial Fibrillation- Acute and medium term results. 2015 German Cardiac Society Annual Meeting.
  56. Noelker, et al. Ablation of AF with PVI and Rotor Elimination: Lessons from the first 60 patients. 2015 German Cardiac Society Annual Meeting.
  57. Noelker, et al. Ablation of AF with PVI and Rotor Elimination: Lessons from the first 60 patients. 2015 German Cardiac Society Annual Meeting.
  58. Spitzer et al. FIRM-Guided AF Ablation: An option for PVI failures in PerAF? 2015 German Cardiac Society Annual Meeting.
  59. Tilz R, Kuck KH et al. Focal Impulse and Rotor Modulation for the Treatment of Atrial Fibrillation Using the Novel 64-Electrode Basket Catheter: 12 Month Outcomes. 2015 German Cardiac Society Annual Meeting.
  60. Shukla G, Zimmerman J, Shir Z, et al. Rotor map and ablation with a novel basket catheter using magnetic remote navigation system for the treatment of atrial fibrillation. Presented at the Orlando International AF Symposium, 2015.
  61. Gonzales MJ, Vincent KP, Rappel WJ, et al. Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria. Europace 2014; 16(suppl 4): iv1-iv2 DOI: 10.1093/europace/euu251.
  62. Hayase J, Faiwiszewski Y, Vampola S, et al. Rotor prevelance and stability predict longer duration of self-terminating ventricular fibrillation episodes. AHA 2014.
  63. Swarup V, Baykaner T, Zaman J, et al. Rotors and focal sources for human atrial fibrillation are spatially and temporally stable. AHA 2014.
  64. Narayan S. Mapping to guide atrial fibrillation ablation. Oral presentation, AHA 2014.
  65. Gonzales M, Vincent K, Rappel WJ, et al. Maintenance and termination of atrial fibrillation in a patient-specific model. FASEB 2014 28:861.1.
  66. Narayan SM, et al. Long-Term Follow-up of Patients with Persistent AF Undergoing the FIRM Strategy. Oral Presentation; Cardiostim, 2014.
  67. Tilz R, Lemes C, Lin T, et al. Comparison of Atrial Fibrillation Rotors Identified by Endocardial Versus Epicardial Rotor Mapping. Oral Presentation; Cardiostim, 2014.
  68. Narayan SM et al. Spatial Reproducibility of Rotors for Persistent Atrial Fibrillation During and Between Procedures Using Focal Impulse and Rotor Modulation. Oral Presentation; Cardiostim, 2014.
  69. Lin T, Rillig A, Bucur T, et al. Focal Impulse and Rotor Mapping (FIRM) in Atrial Fibrillation Using the Novel 64-Electrode Basket Catheter: Acute Outcomes. Poster Presentation; Cardiostim, 2014.
  70. Yoakum S, Greer E, Cooper D, et al. FIRM Ablation for Persistent AF Reduces Recurrence in Blanking Period. Poster Presentation; Cardiostim, 2014.
  71. Schricker A, Baykaner T, Coysh T, et al. Persistent Rotors Explain Post-Ablation Atrial Fibrillation Recurrence. Poster Presentation; Cardiostim, 2014.
  72. Tilz R, Rillig A, Makimoto H, et al. Locations of Human Atrial Fibrillation Rotors. Comparison of Rotor Locations in Patients with Paroxysmal vs Persistent AF. Poster Presentation; Cardiostim, 2014.
  73. Baykaner T, Lalani GG, Schricker A, et al. Diverse Locations of Bi-Atrial Rotors and Focal Sources in Atrial Fibrillation: Similarity Between Extended Series and the Original Confirm Trial. Heart Rhythm 2014; 11(Suppl.5):PO01-129.
  74. Lalani GG, Baykaner T, Schricker AA, et al. Very Long Term Success of Rotor Ablation and Mechanism of Recurrent AF Are Independent of Use of Irrigated vs. Non-Irrigated Ablation Catheters. Heart Rhythm 2014; 11(Suppl.5):PO02-104.
  75. Lemes C, Lin T, Wissner E, et al. Comparison of AF Rotors Identified By Endocardial Versus Epicardial Rotor Mapping. Heart Rhythm 2014; 11(Suppl.5):PO04-85.
  76. Miller JM, Kowal RC, Swarup V, et al. Similar Long-Term Freedom From Persistent or Paroxysmal Atrial Fibrillation After Ablation of Patient-Specific Rotors and Focal Sources: Multicenter FIRM Study. Heart Rhythm 2014; 11(Suppl.5):PO01-127.
  77. Musat D, Narayan SM, Baykaner T, et al. AF Source Location Identification By Focal Impulse And Rotor Modulation Technique During Ablation. Heart Rhythm 2014; 11(Suppl.5):PO06-46.
  78. Narayan SM, Baykaner T, Clopton P, et al. Prevention of Late (3 year) Recurrence of Atrial Arrhythmias By Ablation of Rotor and Focal Sources (FIRM) Compared to Trigger Ablation Alone: Late Follow-up Of The CONFIRM Trial. Heart Rhythm 2014; 11(Suppl.5):PO01-57.
  79. Swarup V, Baykaner T, Krummen D, et al. Acute Termination of Atrial Fibrillation Does Not Predict Long-Term Outcome After Rotor Elimination By Focal Impulse and Rotor Modulation (FIRM): Multicenter FIRM-AF Registry. Heart Rhythm 2014; 11(Suppl.5):PO01-152.
  80. Tilz RR, Lin T, Rillig A, et al. Locations Of Human Atrial Fibrillation Rotors: Rotors Identified Frequently In The Pulmonary Veins. Heart Rhythm 2014; 11(Suppl.5):PO05-75.
  81. Yoakum SH, Greer E, Cooper D, et al. Patient-Tailored Rotor Ablation for Persistent Atrial Fibrillation Reduces Recurrence In The Blanking Period Compared to Trigger-Based Ablation Alone? Heart Rhythm 2014; 11(Suppl.5):PO01-25.
  82. Tomassoni et al. Focal Impulse and Rotor Modulation: Early Experiences. Heart Rhythm 2014; CME satellite symposium.
  83. Tilz et al. First in human: Focal impulse and rotor modulation (FIRM) using the novel 64-electrode basket catheter. The German Society of Cardiology Annual Meeting 2014; Oral Presentation.
  84. Baykaner T, et al. Impact of Clinical Demographics on Three Year Freedom from Atrial Fibrillation after Ablation Guided by Rotors or Focal Sources versus Conventional Ablation Alone: Long Term Analysis of the CONFIRM Trial. J Am Coll Cardiol 2014; 63(12); Supplement A: 1182-119.
  85. Miller JM, et al. Multicenter Validation of Focal Impulse and Rotor Modulation (FIRM) Ablation for Atrial Fibrillation (CONFIRM Multicenter Validation). Presented at the American Heart Association Scientific Sessions. November 2013.
  86. Narayan SM, et al. Precise Rotor Elimination without Concomitant pulmonary vein Isolation for Successful Elimination of Paroxysmal Atrial Fibrillation (PRECISE-PAF). Heart Rhythm 2013. Late Breaking Clinical Trial presented at the 2013 Annual Scientific Session of the Heart Rhythm Society. May 2013.
  87. Mulpuru SK, et al. Human Atrial Tachycardia at Cycle Length 156 ms Cannot Trigger Sustained Atrial Fibrillation After Focal Impulse and Rotor Modification (FIRM). Heart Rhythm 2013; 10 (PO05-188).
  88. Kazmirczak LF, et al. Global Surface ECG Phase Correlation Identifies Rotors in Early Human Ventricular Fibrillation. Heart Rhythm 2013; 10 (PO05-142).
  89. Swarup V, et al. Identification of Stable Atrial Fibrillation Rotors for FIRM Ablation Requires Good Electrode Contact For High Electrogram Fidelity. Heart Rhythm 2013; 10 (PO05-77).
  90. Arshad A, et al. Long-Term Success From FIRM Ablation Is Maintained Even if Acute Endpoint Is Not Achieved. Heart Rhythm 2013; 10 (PO04-133).
  91. Schricker AA, et al. Triggers Consistently Lie Distant to the Atrial Fibrillation That They Initiate. Heart Rhythm 2013; 10 (PO03-115).
  92. Baykaner T, et al. Focal Impulse and Rotor Modulation (FIRM) Ablation Remains Highly Successful In Patients with Unfavorable Demographics for Conventional Atrial Fibrillation Ablation: A substudy of the CONFIRM Trial. Heart Rhythm 2013; 10 (PO03-73).
  93. Lalani GG, et al. Spectral Analysis of Atrial Action Potential Alternans: A Sensitive Clinical Index of Individual Propensity to Atrial Fibrillation. Heart Rhythm 2013; 10 (PO02-96).
  94. Lalani GG, et al. Rotors and Focal Sources For Atrial Fibrillation Drive Activity In the Atria And the Pulmonary Veins. Heart Rhythm 2013; 10 (PO02-49).
  95. Narayan SM, et al. Conservation of Spatial Activation Patterns Between Induced and Spontaneous Atrial Fibrillation In Individual Patients. Heart Rhythm 2013; 10 (PO01-110).
  96. Kowal RC, et al. Results of Focal Impulse and Rotor Modulation (FIRM) for Atrial Fibrillation Are Equivalent Between Patients Treated in San Diego Compared with Sites New to FIRM Ablation: An Extended Multi-center Experience. Heart Rhythm 2013; 10 (MP03-1).
  97. Tung R, et al. Rotors In Human Ventricular Fibrillation And Their Relationship To Ablation Sites For Ventricular Tachycardia. Heart Rhythm 2013; 10 (AB41-05).
  98. Swarup V, et al. Stable Atrial Fibrillation Rotors and Focal Sources Lie in Diverse Bi-Atrial Locations Often Remote from the Pulmonary Veins. Heart Rhythm 2013; 10 (AB34-05).
  99. Kowal RC, et al. Localized Focal Impulse and Rotor Modulation (FIRM) Terminates Atrial Fibrillation into Micro-Reentry, Residual Atrial Tachycardia or Sinus Rhythm: A Unifying Mechanistic Hypothesis. Heart Rhythm 2013; 10 (AB33-06).
  100. Narayan SM, et al. Atrial Fibrillation Sources Targeted for Focal Impulse and Rotor Modulation (FIRM) Are Stable in Location for Thousands of Cycles. Heart Rhythm 2013; 10 (AB12-05).
  101. Narayan SM, et al. FIRM Ablation at Rotors and Focal Sources Has Similarly High Efficacy For Paroxysmal and Persistent Atrial Fibrillation. J Amer Coll Cardiol 2013; 61(10): ACC Oral Presentation E328.
  102. Krummen DE, et al. Procedural Success in the CONFIRM Trial is Independent of Use of Irrigated or Non-irrigated Ablation Catheters. Circulation 2012.
  103. Baykaner T, et al. Heart Failure, Obesity and Sleep Apnea May Mediate Atrial Fibrillation by Enabling Sustaining Rotors. Circulation 2012.
  104. Krummen DE, et al. Focal Impulse and Rotor Modulation-Guided Ablation More Efficiently Prolongs Atrial Fibrillation Cycle Length than Convention Ablation. Circulation 2012.
  105. Elimination of Sources for Human Atrial Fibrillation (Focal Impulse and Rotor Modulation, FIRM) Organizes and Acutely Terminates AF Prior to Pulmonary Vein Isolation: A Multicenter Experience. Circulation 2012.
  106. Rapid Acute Termination Of Atrial Fibrillation By Focal Impulse And Rotor Modulation. Cardiostim Abstract 2012.
  107. Surface ECG Phase Correlation Predicts Human Ventricular Fibrillation Rotors. Cardiostim Abstract 2012.
  108. Percutaneous Detection of Human Ventricular Fibrillation Rotors. Cardiostim Abstract 2012.
  109. Morris DJ, et al. Increased Global Surface ECG Phase Correlation Predicts Human Ventricular Fibrillation Rotors. HRS 20012, P03-150.
  110. Krummen DE et al. Percutaneous Detection of Electrical Rotors That Drive Human Ventricular Fibrillation. HRS 2012, Poster P02-149.
  111. Krummen DE, et al. Physiologically- Guided Ablation Reduces Need for Conventional Ablation of Atrial Fibrillation. HRS 2012, Poster P02-116.
  112. Baykaner T, et al. Determinants of the Number of Localized Sources for Human Atrial Fibrillation. HRS 2012, Poster P02-52.
  113. Krummen DE, et al. Ventricular Fibrillation Rotors Are Located in Both Ventricles in Patients with and without Structural Heart Disease. HRS 2012, Featured Poster P01-126.
  114. Enyeart MW, et al. Correlation of Electrogram Characteristics and Localized Sources for Human AF. HRS 2012, Featured poster P01-105.
  115. Narayan SM, et al. Rotors and Focal Beat Sources for Human Atrial Fibrillation Migrate Within Limited Constrained Areas. HRS 2012, Moderated poster MP02-04.
  116. Narayan SM, et al. Sustaining Rotors and Focal Beats for Human Atrial Fibrillation Are Unrelated to Sites of Fractionated Electrograms. HRS 2012, Oral presentation AB35-05.
  117. Hopper K, et al. Success of Focal Impulse & Rotor Modulation for Human Atrial Fibrillation Reflects the Adequacy of Basket Recordings. HRS 2012 Oral presentation AB03-06.
  118. Narayan SM, et al. Targeted Ablation at Sources Alone (Focal Impulse and Rotor Modulation, FIRM) Acutely Terminates or Slows Human Atrial Fibrillation. HRS 2012, Oral Presentation AB02-03.
  119. Narayan SM, et al. Relationship of Localized Sources for Human Atrial Fibrillation to Complex Fractionated Electrograms (Top Poster Finalist). J Am Coll Cardiol. 2012; 59.
  120. Determinants of Localized Sources for Human Atrial Fibrillation (poster presentation). J Am Coll Cardiol. 2012;59.
  121. Sehra R, et al. Elimination Of Localized Source Rhythms For Human Atrial Fibrillation Is Highly Cost Effective. AHA 2011 (Top Poster).
  122. Krummen DE, et al. Rotors and Focal Sources Frequently Localize Outside Anatomically-Based Ablation Sites. AHA 2011, Expanded oral presentation; Circulation 2011: Ctrl# 15602.
  123. Narayan SM, et al. Elimination of Recurrent Atrial Fibrillation by Focal Impulse and Rotor Modulation (FIRM) Alone. AHA 2011, Oral presentation.
  124. Rapid Termination of Human Atrial Fibrillation by Ablation At Localized Sources: Focal Impulse and Rotor Modulation (FIRM). AHA 2011, Oral presentation.
  125. Right Atrial Rotors and Focal Impulses In Human Atrial Fibrillation May Explain Success Rates of Conventional Ablation. AHA 2011 (poster presentation). Circulation 2011: Ctrl# 11178.
  126. Migration Loci of Rotors for Human Atrial Fibrillation Define Ablation Targets for Focal Impulse and Rotor Modulation (FIRM). AHA 2011, Expanded oral presentation. Circulation 2011; Ctrl# 11131.
  127. Sehra R, et al. Elimination of Localized Source Rhythms for Human Atrial Fibrillation is Highly Cost Effective. J Cardiovasc Electrophysiol 2011; 22 (Supplement 1): S23.
  128. Detection of Rotors that Drive Human Atrial Fibrillation. Venice Arrhythmias 2011. J Cardiovasc Electrophysiol 2011; 22 (Supplement 1): S24.
  129. Ablation of Right Atrial Rotors Acutely Terminates Human Atrial Fibrillation. Venice Arrhythmias 2011. J Cardiovascular Electrophysiol 2011; 22 (Supplement 1): S25.
  130. Rapid Acute Termination of Human Atrial Fibrillation: Focal Impulse and Rotor Modulation. Venice Arrhythmias 2011. J Cardiovasc Electrophysiol 2011; 22 (Supplement 1): S25.
  131. Relationship of Localized Rotors in Human Atrial Fibrillation to Fractionated Electrograms. 2011 Asia Pacific Heart Rhythm Society, Fukuoka, Japan.
  132. Rapid Termination and Elimination of Human Atrial Fibrillation: Ablation at Rotors and Focal Drivers (poster presentation). European Heart J 2011; Supplement: 84897.
  133. Demonstrating Localized Electrical Rotors That Perpetuate Human Atrial Fibrillation (poster presentation). European Heart J 2011; Supplement: 84891.
  134. Localized and Spatially Constrained Sources in Human Atrial Fibrillation (poster presentation). European Heart J 2011; Supplement: 84885.
  135. Sehra R, et al. Reentrant Rotors and Focal Beats May Cause Human Atrial Fibrillation (poster presentation). European Heart J 2011; Supplement: 84878.
  136. Sehra R, et al. Human Atrial Fibrillation May Be Caused By Right Atrial Drivers (poster presentation). European Heart J 2011; Supplement: 84877.
  137. Acute Termination of Paroxysmal and Persistent Atrial Fibrillation By Focal Impulse and Rotor Modulation (oral presentation). Europace 2011; Supplement: 40419 (abstract 865).
  138. Localized and Stable Focal Impulses and Electrical Rotors During Human Atrial Fibrillation (poster presentation) Europace 2011; Supplement: 40417 (abstract P531).
  139. Methods for Demonstration of Localized Electrical Rotors In Human Atrial Fibrillation. Europace 2011 (poster presentation); Supplement: 40418 (abstract P344).
  140. Sehra R, et al. Right Atrial Electrical Rotors and Focal Impulses As Drivers for Human Atrial Fibrillation. Europace 2011 (poster presentation); Supplement: 40415.
  141. Sehra R, et al. Rotors and Focal Beats In Human Atrial Fibrillation Lie Near and Remote from Pulmonary Veins. Europace 2011 (oral presentation); Supplement: 40416.
  142. Mulpuru SK, et al. Borderzone May Contribute to Wavebreak in Human Ventricular Fibrillation: Evidence from Simultaneous Multisite Biventricular Mapping. HRS 2011; 8(5S): P04-119.
  143. Sehra R, et al. A Localized, Non-isolated Region of Atrial Fibrillation During Sinus Rhythm. HRS 2011 (poster presentation); 8(5S): P04-181.
  144. Sehra R, et al. Acute and Long-Term Elimination of Persistent AF By Ablating a Single Right Atrial Site (abstract: poster). HRS 2011; 8(5S): P03-174.
  145. Narayan SM, et al. Detection of Electrical Rotors and Repetitive Focal Impulses in Human Atrial Fibrillation. HRS 2011 (poster presentation); 8(5S): P01-113.
  146. Rappel WJ, et al. Patient-Specific Modeling of Atrial Fibrillation Termination By Ablation in Humans. HRS 2011 (poster presentation); 8(5S): P02-104.
  147. Krummen DE, et al. Correlation of Electrical Rotors and Focal Sources with Sites of Centrifugal Stepdown in Dominant Frequency in Human Atrial Fibrillation. HRS 2011 (poster presentation); 8(5S): P02-80.
  148. Krummen DE, et al. Potential Localized Sources for Human Atrial Fibrillation Lie Near But Also Remote From Pulmonary Veins. HRS 2011 (poster presentation); 8(5S): P02-72.
  149. Krummen DE, et al. Electrical Rotors Exist in Human Atrial Fibrillation. HRS 2011(poster presentation); 8(5S): P02-54.
  150. Narayan SM, et al. Electrical Rotors and Repetitive Focal Beats Are Localized Sources for Human Atrial Fibrillation. HRS 2011 (featured poster); 8(5S): P01-55.
  151. Narayan SM, et al. Rapid Acute Termination of Human Atrial Fibrillation by Focal Impulse and Rotor Modulation: Early Human Experience. HRS 2011 (featured oral innovators presentation); 8(5S): AB02-4.
  152. Narayan SM, et al. Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation: The CONFIRM Trial. HRS 2011 (LBCT); 8(5S): LB-04.

Abbott EP is committed to continually advancing the understanding of the sustaining mechanisms of AF and is actively engaged with institutional research partners to undergo basic science translational research initiatives, which include animal studies and bench research. Company funding is available for those initiatives with sufficient merit, with an “overhead”/F&A limit of 23%.