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Get your rhythm back.

Serious heart rhythm disorders called arrhythmias, affect the lives of millions of people daily. Unfortunately, most treatments for these conditions are generic and one-size-fits-all, with mixed results.


But there’s hope.


We believe there is a better way to treat serious heart rhythm disorders such as atrial fibrillation and ventricular tachycardia. Using Abbott Electrophysiology’s technology, doctors can identify the sources of arrhythmias that are unique to each person. Now treatment can be tailored to your individual needs.


Find Your Source.
Get Tailored Therapy.
Get Your Rhythm Back.

Find a doctor near you who is using the Topera Rotor Mapping System

The most common heart rhythm disorder, atrial fibrillation (AF, or afib) is a serious global public health problem which affects millions of people around the world. If left untreated, AF doubles the risk of heart-related deaths and also increases stroke risk by up to 500%. Unfortunately, although it is such a serious health problem, AF has historically been difficult to treat with an acceptable degree of success.

In response to this unaddressed need, Abbott, Inc. has developed a unique 3D analysis and mapping solution (the Abbott 3D Mapping System), which consists of the RhythmView Workstation and FIRMap diagnostic catheter. The Abbott 3D Mapping System has been designed to enable physicians to view the electrical activity of the heart, thereby supporting the diagnosis and patient-specific treatment planning for a variety of heart arrhythmias including atrial fibrillation, atrial flutter, atrial tachycardia, and ventricular tachycardia.

The Abbott 3D Mapping System received FDA clearance in 2013 and is now in routine use at several leading medical centers throughout the United States.

Multicenter Registry

Multicenter FIRM Registry1
Reproducing the Results of the CONFIRM trial2

The results of the CONFIRM Trial were reproduced in an independent, multi-center study and included 10 centers in the United States.


Introduction

The success of pulmonary vein isolation (PVI) for atrial fibrillation (AF or Afib) may be improved if stable AF sources identified by mapping the Focal Impulse and Rotor Modulation (FIRM) are also eliminated. The long-term results of this approach are unclear outside the centers where FIRM was developed; thus, the authors assessed outcomes of FIRM-guided AF ablation in the first cases at 10 experienced centers.study4

Methods

Patients included paroxysmal AF, persistent AF and longstanding persistent AF. The only exclusion criterion was an inability or refusal to provide written informed consent. The authors prospectively enrolled (n = 78) consecutive patients (61 ± 10 years) undergoing FIRM-guided ablation for Afib for persistent (n = 48), longstanding persistent (n = 7) or paroxysmal (n = 23) AF. AF recordings from both atria with a 64-pole basket catheter were analyzed using RhythmView®, a novel mapping system designed by Topera Medical, now Abbott Electrophysiology. Identified rotors/focal sources were ablated, followed by PVI.

Key Findings

  • 78 consecutive patients
  • AF sources detected in 100% of patients
  • 25.3% right atrial sources
  • Non-randomized registry study
  • Further validation that rotors are a sustaining mechanism of AF

Conclusion

In this multicenter learning curve experience of FIRM mapping, mapping and elimination of patient-specific rotors and focal sources with trigger isolation provided >80% single procedure AF elimination in patients predominantly with persistent AF. These acute and chronic results were similar to those originally reported from FIRM by the originating group. FIRM-guided ablation for AF and other complex arrhythmias has a rapid learning curve at experienced ablation centers.


  1. Miller JM, Kowal RC, Swarup V, et al. Initial Independent Outcomes from Focal Impulse and Rotor Modulation Ablation for Atrial Fibrillation: Multicenter FIRM Registry. J Cardiovasc Electrophysiol. 2014; 25(9):921-929.
  2. Narayan SM, Krummen DE, Shivkumar K, Clopton P, Rappel W-J, and Miller JM. Treatment of Atrial Fibrillation by the Ablation of Localized Sources-CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) Trial. J Am Coll Cardiol 2012; 60(7):628-3

 

These trials were supported by grants from the National Institutes of Health and the Doris Duke Charitable Foundation. Please refer to the study citations to review all reported author conflicts of interest.